Digital Trials pipeline configured for WES

Source-only snapshot of the cluster branch for WES execution. Large
reference files (HPA/MANE/ensemble FASTA, model weights, ~597 MB) are
omitted: they are baked into the container images at build time and
mounted from the dreamdock-data PVC at runtime, and exceed the Gitea
request size limit.

Pipeline entry point is main.nf, which orchestrates the biotransformer,
conplex and tissue modules as a single workflow. Ligand inputs are read
from the eureka workspace; protein_zarr and chembl_db come from the
dreamdock-data PVC.

Dockerfile_tissue

@@ -0,0 +1,20 @@
+# Use the specified Micromamba base image with CUDA 11.7
+FROM mambaorg/micromamba:2.1.1
+
+
+USER root
+ARG MAMBA_DOCKERFILE_ACTIVATE=1
+
+
+RUN micromamba install -y python=3.9 procps-ng pandas numpy && \
+    pip install pandas numpy && \
+    micromamba clean --all --yes
+
+
+# Package into python script for running in nextflow
+COPY drug_tissue_distribution.py /home/omic/drug_tissue_distribution.py
+
+# Copy reference files
+COPY HPA_normal_ihc_data.tsv /home/omic/
+COPY MANE_all_transcipts.csv /home/omic/
+COPY digital_patient_extract_metrics.py /home/omic/